SP-0296: Challenges in combining radiation and chemo-radiation with PARP inhibitors
نویسندگان
چکیده
منابع مشابه
Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation.
Radiation therapy remains a promising modality for curative treatment of localized prostate cancer, but dose-limiting toxicities significantly limit its effectiveness. Agents that enhance efficacy at lower radiation doses might have considerable value in increasing tumor control without compromising organ function. Here, we tested the hypothesis that the PARP inhibitor ABT-888 (veliparib) can e...
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Ewing sarcomas (ES) harbor a chromosomal translocation that fuses the EWS gene to an ETS transcription factor, most commonly Friend leukemia integration 1 (FLI1). The EWS-FLI1 fusion protein acts in a positive feedback loop to maintain the expression of PARP-1, which is involved in repair of DNA damage. Here, we examine the effects of PARP-1 inhibition and radiation therapy on Ewing sarcomas. I...
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Androgen deprivation therapy (ADT) has been the standard of care for advanced prostate cancer (PCa) for decades, yet men with this condition inexorably develop resistance to ADT and progress to metastatic castrationresistant PCa (mCRPC) [1]. Second generation androgen receptor (AR) signaling inhibitors such as enzalutamide (ENZ) can prolong survival in mCRPC patients, however, ENZ-resistance al...
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Poly (ADP-ribose) polymerases (PARPs) are a family of enzymes involved in cellular homeostasis, including DNA transcription, cell-cycle regulation, and DNA repair (1, 2). PARPs can detect DNA damage and bind to DNA single strand breaks (SSBs) through their N-terminal zinc finger domains. DNAbinding activates theC-terminal catalytic domain, which hydrolyzesNAD to attach poly ADP-ribose (PAR) pol...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2016
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(16)31545-6